Part of a building undergoing renovation collapsed on Wednesday morning near Rothschild Boulevard in central Tel Aviv.
Large numbers of police, firefighters and rescue crews were sent to the scene.
Tel Aviv, Israel's economic capital, is a vast construction site, with hundreds of buildings under construction or renovation. Israel has strict building standards and frequent inspections, which developers often describe as overly meticulous. Bureaucracy can delay projects by several years.
No information was immediately available on casualties, the cause of the collapse or whether anyone was trapped.